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A historical perspective and recent research point to some form of carbohydrate restriction as a likely candidate for a new nutritional approach, and we present a thematic review regarding carbohydrate restriction.

The examination of diets before modernization can remind us of the remarkable ability of humans to adapt to their environment and can provide a context within which to view current diets.

The main similarities in metabolism between LCDs and starvation are that there is no (or little) intake of exogenous carbohydrate and that there is a shift from the use of glucose as fuel toward the use of fatty acids and ketones as fuel.In addition, postabsorptive carbohydrate oxidation decreased progressively over the 7-d duration, and this decline was greater than the decline in glucose uptake.This means that the rate of nonoxidative glucose disposal (ie, carbohydrate storage) increased in the postabsorptive state with the 5% carbohydrate diet.With the 5% carbohydrate diet, serum glucose initially declined but then returned to baseline after a few days.Whereas fasting insulin did not differ between the 2 diets, the 24-h area under the curve (AUC) for insulin was 50% lower with the 5% carbohydrate diet than with the 60% carbohydrate diet.

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The change in lifestyle of several North American aboriginal populations occurred as recently as the late 1800s, and the numerous ensuing health problems were extensively documented (3-5).

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  1. Kim signs on, and the Cyrano team — Byeong-hoon's one-time drama student Min-yeong (Park Shin-hye), plus older Cheol-bin (Park Chul-min) and younger Jae-pil (Jeon Ah-min) — set to work, constructing elaborate scenarios in which Seon-ah is the unwitting target and feeding lines to Hyeon-gon through an earpiece.

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